Objective: We aimed to find the alterations in biofilm formation of Acinetobacter baumannii ( A. baumannii ) during adaptation to colistin resistance under colistin stress. Materials and Methods: Eighteen patients with an isolation of A. baumannii (nine colistin resistant and nine colistin susceptible) and additionally two patients that develop colistin resistant A. baumannii infection during hospital stay were included the study. For in vitro adaptation study, four...
Topics: Acinetobacter baumannii, colistin resistance, biofilm, adaptation, virulence
Abstract Objective: During the COVID-19 pandemic, antimicrobial and antifungal stewardship programs have lost their priority. Although all parenteral antifungals were used with the recommendations of infectious diseases specialists in the pre-pandemic period, most consultations were delayed during the pandemic because of the workload of infectious diseases specialists. In this period, antifungal treatments in hospitalized patients were managed by mostly primary physicians. Therefore, we aimed...
Topics: COVID-19, antifungal consumption, amphotericin B, azole, echinocandin, antifungal stewardship,...
Abstract The spread of infectious diseases claimed more lives than battle wounds during the Crimean War (1853-1856). Istanbul, then the Ottoman capital, was transformed into a medical hub where new ideas were tested and exchanged among physicians, surgeons and nurses from all over Europe to control the spread of disease. Although the most well-known figure of this international effort was Florence Nightingale, the medical community serving in Istanbul at the time had many other heroes and...
Topics: Crimean War, infectious diseases, Florence Nightingale, hospital architecture, healthcare facilities
Abstract Central nervous system nocardiosis is rare but has high morbidity and mortality. Immunocompromised patients who have malignancies such as lymphoma, infections such as human immunodeficiency virus (HIV), and bone marrow or solid organ recipients are particularly vulnerable to infection. However, here, we present a patient who developed nocardiosis and recurrent brain abscesses despite having no immunodeficiency problems. The abscess recurred despite total abscess excision and parenteral...
Topics: nocardiosis, brain abscesses, immunocompetent
Abstract A 19-year-old woman with a history of tuberculosis (TB) in her family presented to the infectious disease clinic of our hospital with right flank pain, nausea, vomiting, a 10-kg weight loss, and decreased urine volume for the past two months. Empirical anti-TB treatment was initiated due to her family history of tuberculosis, a positive purified protein derivative skin test, and the presence of a nodule in the posterobasal segment of the lung upon F18-FDG PET/CT. We aimed to present...
Topics: Tuberculosis, F18-FDG PET/CT, infectious disease
Abstract Background: We described the outcomes of healthcare workers (HCWs) who have been exposed to COVID-19. Materials and Methods: We included the HCWs exposed COVID-19 and admitted to the COVID-19 outpatient clinic between March 13 and August 31, 2020, at a university hospital in Ankara, Turkey. The clinical data and exposure status were retrospectively obtained from medical records. Results: We analyzed 809 admissions of 690 HCWs. In total, 490 HCWs were admitted after suspected exposure...
Topics: Healthcare worker (HCW), COVID-19, SARS-CoV-2, exposure, asymptomatic infection
Abstract Objective: The main purpose of chronic hepatitis B (CHB) treatment is to improve the patients’ life quality and prevent the disease from progressing to cirrhosis or hepatocellular carcinoma. Continuous suppression of hepatitis B virus (HBV) DNA with nucleoside or nucleotide analogues is the most critical way to achieve this goal. This study aimed to evaluate the CHB patients retrospectively followed up with tenofovir disoproxil fumarate (TDF) treatment. Materials and Methods: The...
Topics: tenofovir disoproxil fumarate, hepatitis b infection, liver
Abstract A nulliparous previously healthy pregnant woman who suffered from postpartum spinal epidural abscess due to Streptococcus agalactiae which probably evolved during delivery.
Topics: Streptococcus agalactiae, spinal epidural abscess, postpartum
Abstract Objective: Patients with hematological malignancies (HMs) have a substantial incidence of febrile neutropenic episodes. Gram-negative bacteremia (GNB) is still the major cause of these episodes. We evaluated the factors associated with GNB and mortality of bacteremic patients with HMs in a high-resistance setting. Materials and Methods: We conducted a prospective cohort study from March 2018 to June 2019 with 66 bacteremic and 132 non-bacteremic patients. Regression analyses were used...
Topics: Bacteremia, Gram-negative bacteria, hematological neoplasms, febrile neutropenia, anti-bacterial...
Abstract Objective: This study aimed to evaluate bloodstream infections caused by Stenotrophomonas maltophilia in immunocompetent patients with respect to clinical features and risk factors for mortality. Methods: We reviewed bloodstream infections detected between January 1, 2012, and July 1, 2021, to identify nosocomial S. maltophilia bacteremia in Koşuyolu Research and Training Hospital. Results: We identified a total of 97 patients with S. maltophilia bloodstream infections. Of these,...
Topics: Stenotrophomonas maltophilia, bloodstream infections, mortality
Abstract Objective: We aimed to detect the risk factors for invasive candida infections by evaluating the fungal strains cultivated from samples taken in a medical intensive care unit (ICU). Materials and Methods: We investigated fungal growths between January 1, 2016, and December 1, 2018, retrospectively. All reported fungal growths and demographic characteristics, clinical features, treatments and outcomes of the patients with fungal growths were recorded. Results: Fungal growths were...
Topics: candidemia, candida score, c. parapsilosis, intensive care unit
Abstract Italian physician Dr. Luigi Mongeri (1815–82), who graduated from the School of Medicine in Pavia and worked as chief physician at Süleymaniye and Toptaşı Lunatic Asylums, introduced important reforms that shaped modern psychiatry in the Ottoman Empire. Before the appointment to Süleymaniye, Mongeri worked as a sanitary physician in the International Quarantine Organization from 1840 to 1849. This article examines Mongeri’s encounter with epidemics while focusing on his work on...
Topics: History of medicine, cholera, Luigi Mongeri, epidemics
Abstract Background: Although there have been significant improvements in treatment strategies, hepatitis C infection is still among the most critical public health problems worldwide. Upon entry of hepatitis C virus (HCV) into host liver cells, many antagonist immune responses are induced, including the production of regulatory T cells (Tregs). The main function of Tregs is coordinating an appropriate immune response, including suppression of this response once it is no longer needed. Tregs...
Topics: Flow cytometry, hepatitis C virus, immunomodulation, regulatory T cell
Abstract Objective: This study aimed t o investigate the detection rate of Gardnerella vaginalis by multiplex PCR test in the genitourinary samples of male patients with suspected urethritis and related symptoms. Materials and Methods: A total of 144 male patients who presented to our department between February 2021 and October 2021, either with urinary symptoms or concerns following unprotected sex, were included in the study. A total of 128 (88.9%) first-void urine samples, 15 (10.4%)...
Topics: Gardnerella vaginalis, male, polymerase chain reaction, urethritis
The history of scientific publishing is assumed to begin with the publication of Philosophical Transactions of the Royal Society in March 1665 by Henry Oldenburg who was the publisher and the editor, but also the first secretary of the Royal Society (1). Since then, more than 55- million of articles have been published and currently every year 500.000 new articles are estimated to be produced by researchers. Pubmed has indexed more than 29-million articles as of December 2018.
Topics: scientific publishing, medical journal, online journal
Abstract Objective: Healthcare workers (HCWs) are at high risk in terms of influenza infection. Despite the fact that the HCWs were encouraged to be vaccinated against influenza as one of the prior target group, the vaccine coverage rates are low. This study aimed to assess HCWs’ knowledge, attitude and beliefs against influenza infection and influenza vaccination at a public hospital in Turkey. Materials and Methods: At a 1,100-bed hospital in which 2766 HCWs were employed, a face-to-face...
Topics: healthcare workers, influenza vaccination, influenza infection and healthcare workers, influenza...
A 40-year-old female patient without any medical history presented to the emergency department with a 3-day history of neck pain and headache. She did not show any other symptoms. Her initial laboratory tests showed slightly increased C-reactive protein (6 mg/L; normal range 0-5 mg/L) and a normal white cell count. There were not observed any other abnormal laboratory finding (leukocyte, 7.4 x 103/uL; hemoglobin, 11.7 gr/dL; platelet, 172 x 103/uL; aspartate aminotransferase, 27 U/L; alanine...
Topics: COVID-19, MRI, neurologic findings, viral pneumonia
Abstract Syphilitic uveitis is mostly observed in patients with comorbid risk factors such as human immunodeficiency virus (HIV). Here, we present a case of syphilitic uveitis that began with painless oral ulcers in an HIV negative male, whose primary and secondary phases were not detected. Case: A 47-year old male with no significant medical history arrived at the Ear-Nose-Throat Department in September 2018 with a sore throat, fatigue, fever, and painless ulcers in his mouth. After a while,...
Topics: Neurosyphilis, ocular manifestation, HIV negative
Abstract Objective: As HIV infection is becoming a chronic entity, the role of primary care physicians (PCPs) in diagnosis and treatment is getting more significant. We aimed to assess the attitude and competency of the PCPs about HIV infection compared to other specialties and describe the areas for improvement. Materials and Methods: A survey was conducted between 1-31 May 2017 among physicians from different specialties. The questions related to HIV infection in their clinical practice,...
Topics: human immunodeficiency virus, primary health care, healthcare providers, training programs
Remdesivir is a novel nucleotide analogue antiviral drug with in vitro activity against severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) (1). Food and Drug Administration (FDA) and Drug Controller General of India have authorized the emergency use for the treatment of COVID-19 under an Emergency Use Authorization (EUA) (2). The original trademark name of remdesivir with proven and approved efficacy developed by Gilead is Veklury®. Veklury® is licenced in over 50 countries around...
Topics: COVID-19, SARS-CoV-2, Remdesivir
Infectious Diseases and Clinical Microbiology
7
7.0
Jun 13, 2022
06/22
by
Harika Öykü Dinç, İlker İnanç Balkan, Beyhan Budak, Mehmet Demirci, Doğukan Özbey, Rıdvan Karaali, Bilgül Mete, Günay Can, Sevgi Ergin, Bekir Kocazeybek, Neşe Saltoğlu
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Abstract We aimed to describe the antibody response against SARS-CoV-2 after inactivated COVID-19 vaccine in elderly individuals. SARS-CoV-2 IgG levels were measured in the blood samples of 126 volunteers over the age of 60. The antibody positivity rate was 42.8% after the first dose and 96.8% after the second dose of the vaccine. The median antibody titers after two vaccine doses were 561.3AU/mL and 43AU/mL, respectively( p <0.001). After vaccination, 22.2% of the participants had...
Topics: COVID-19, SARS-CoV-2, inactivated vaccine, CoronaVac, antibody
Infectious Diseases and Clinical Microbiology
7
7.0
Aug 31, 2021
08/21
by
Mahir Kapmaz, Özlem Doğan, Hacer Aktürk, Berna Özer, Elif Nurtop, Cansel Vatansever, Gülin Özcan, Aydın Çelikyurt, Fidan Khalilova, Ayşe Okan, Said İncir, Cansın Saçkesen, Önder Ergönül, Füsun Can
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Abstract Objective: We aimed to describe the infectivity of adult and pediatric COVID-19 patients in the presence of viral shedding and anti-SARS-CoV-2 antibody response. Materials and Methods: A total of 408 consequent samples from eleven adults and five pediatric patients with SARS-CoV-2 infection were included. Reverse transcription-polymerase chain reaction (RT-PCR) and viral culture were performed for the samples obtained every other day from saliva, nasopharynx, feces, serum, urine, and...
Topics: Infectivity, SARS CoV 2 shedding, live virus
Abstract Objective: Information on characteristics and outcomes of coronavirus disease 2019 (COVID-19) patients in Turkey is limited. We aimed to describe the characteristics and outcomes of patients hospitalised with COVID-19 and compare patients who required intensive care unit (ICU) admission with those who did not require it. Materials and Methods: This retrospective cross-sectional study was conducted in a tertiary care hospital in Istanbul. A total of 215 patients hospitalised with...
Topics: Infections, Pneumonia, Critical Care
Abstract Clostridioides difficile -associated pseudomembranous colitis (PMC) is a life-threatening inflammatory bowel disease. Here, we aimed to present a 40-year-old woman at 25 weeks of gestation whose pregnancy was terminated earlier than expected. Unfortunately, despite fidaxomicin and oral vancomycin, the patient’s diarrhea did not improve, and she had to undergo a subtotal colectomy. C. difficile infections developing in pregnant women can be catastrophic for both baby and maternal...
Topics: Clostridioides difficile, pregnant, colectomy, colitis
Infectious Diseases and Clinical Microbiology
11
11
Mar 10, 2022
03/22
by
Ege Anıl Uçar, Mehmet Batuhan Karakuş, Mustafa Güldan, Selin Merve Şahin, Uluman Şişman, Arzu Baygül, Sinem Ezgi Gülmez
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Abstract ABSTRACT Objective: Irrational use of antibacterials is a concern during the COVID-19 pandemic. Hospital pharmacoepidemiology studies are important for evaluating the rational use of medicines, especially antibacterials, during pandemics. Defined daily doses (DDD) and drug utilization 90% (DU90%) are established methods for the evaluation of drug utilization. We aimed to evaluate antibacterial utilization in a tertiary hospital setting at Koç University Hospital (KUH). Materials...
Topics: Pharmacoepidemiology, antibiotics, drug utilization, COVID-19 pandemic
Infectious Diseases and Clinical Microbiology
15
15
Jun 13, 2022
06/22
by
Abdurrahman Gülmez, Ahmet Naci Emecen, Mestan Emek, Belgin Ünal, Koray Ergünay, İbrahim Mehmet Ali Öktem, Özgen Alpay Özbek
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Abstract Objective: West Nile Virus (WNV), which causes widespread outbreaks in different parts of the world, is a risk to public health in Turkey, too. Community-based study data are needed to identify measures against possible outbreaks. This study aimed to determine the seroprevalence of community-based WNV in Manisa and to investigate the relationship between sociodemographic and socioeconomic variables. Methods: We included individuals older than two years of age (N=1,317,917)...
Topics: West Nile virus, seroprevalence, ELISA
Abstract Fasciola hepatica is a trematode that is visible to the naked eye. The diagnosis can be made by serology or by clinical improvement and decrease of eosinophilia after triclabendazole treatment or by finding parasite eggs in the stool. Sometimes the diagnosis is possible during unnecessary surgery, laparoscopic cholecystectomy, and endoscopic retrograde cholangiopancreatography (ERCP). F. hepatica infection should be considered in patients with typical clinical findings; the elevation...
Topics: Fasciola hepatica, obstructive jaundice, eosinophilia
Abstract Objective: Nosocomial infections (NIs) are major health problems with morbidity and mortality. Geriatric patients require intensive care unit (ICU) admission more frequently, and serious challenges occur during treatment. We aimed to evaluate the risk factors of NI and mortality in geriatric patients admitted to the ICU. Materials and Methods: The study was conducted between April 2018 and April 2019 in two hospitals. We prospectively recorded the data on the forms prepared according...
Topics: Nosocomial infection, geriatrics, intensive care units
Abstract Objective: This study aimed to assess the performance of the CURB-65, the quick COVID-19 severity index (qCSI), and the Brescia-COVID respiratory severity scale (BCRSS) scores in predicting ICU (intensive care unit) hospitalization and in-hospital mortality in emergently hospitalized patients with COVID-19 pneumonia. Materials and Methods: We retrospectively reviewed the emergently hospitalized 258 patients with COVID-19 pneumonia consecutively. The required sample size was calculated...
Topics: COVID-19, CURB-65, scoring systems
Abstract Objective: Since the angiotensin-converting enzyme (ACE) is the functional receptor for SARS-CoV-2, predominantly expressed by the alveoli, SARS-CoV-2 primarily involves the lungs. Aside from the lungs, ACE is expressed in other organs, including the thyroid gland. This study aimed to evaluate the incidence of thyroid dysfunction (TD) in patients admitted to the intensive care unit (ICU) with critical COVID-19, with inflammatory markers and disease severity, compared to patients with...
Topics: COVID-19, thyroid dysfunction, euthyroid sick syndrome, inflammatory markers, cardiac troponin T,...
Objective: Giardiasis is a common disease, and clinical forms can vary based on the assemblage types of the parasite. Detailed information on the subgenotypes may indicate the transmission routes and enlighten the gaps in the epidemiology of the disease. This study aims to reveal the occurrence of giardiasis in Thrace, Turkey, and assemblage types of Giardia duodenalis . Materials and Methods: In total, 573 stool samples taken from the individuals applied to Tekirdağ Central State...
Topics: Giardia duodenalis, assemblage, subgenotype, human, Turkey
A 38-year-old man presented to the hospital with complaints of fever and multiple lesions on his face, hands, and arms. The lesions were appeared five days earlier before admission as painless small papules and developed into larger lesions with the darkish center. He was experiencing a fever for the last 24 hours. He was a farmer, he sacrificed and butchered a bull at the Eid al-Adha, ten days ago. He reported that he was healthy previously and did not use any drug. On physical examination,...
Topics: Anthrax, Orf
Infectious Diseases and Clinical Microbiology
9
9.0
Oct 7, 2019
10/19
by
Bilgehan Aygen, Neşe Demirtürk, Orhan Yıldız, İlhami Çelik, Deniz Kamalak Güzel, Gülden Ersöz, Ayşe Batırel, Bahar Örmen, Faruk Karakeçili, Pınar Korkmaz, Nazan Tuna, Alper Şener, Rıza Aytaç Çetinkaya, Emine Türkoğlu, Güliz Evik, Nesrin Türker, Umut Devrim Binay, Ercan Yenilmez, Gökmen Zararsız
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Abstract Objective: Ombitasvir/paritaprevir/ritonavir (OMV/PTV/r) + ribavirin (RBV) combination improved the efficacy, safety, and tolerability of the treatment of chronic hepatitis C virus (HCV) genotype 4 infection. We described the effectiveness and safety of OMV/PTV/r + RBV therapy in patients with genotype 4 infection. Materials and Methods: In this prospective cohort study, HCV genotype 4-infected patients treated with OMV/PTV/r + RBV (n=55) who were registered in a national database were...
Topics: hepatitis C virus, therapy, safety, tolerability
Abstract Objective: Irrational use of antibiotics is a significant global health care problem which causes antibiotic resistance. Population-based antibiotic prescribing data in dentistry have not been extensively studied in Turkey and many other countries. This study aimed to describe the antibiotic prescription attitudes of dentists in Turkey by using population-based data. Materials and Methods: Data on systemic antibiotics prescribed by dentists to the Turkish Medicines and Medical Devices...
Topics: Dental, antibiotic usage, prescribing practice
Abstract Norwegian scabies, which is a highly contagious variant of scabies, is a common parasitic infestation in elderly persons living in care homes. Clinical symptoms may be different in this patient group (slow onset and insidious progression, often without intense itching) with the addition of comorbid conditions, such as dementia and neurological diseases. Healthcare workers should be aware of this form of scabies, which is more common in elderly and cognitively impaired patients. Early...
Topics: scabies, elderly, dementia, mites, Sarcoptes scabiei
Infectious Diseases and Clinical Microbiology
8
8.0
Aug 31, 2020
08/20
by
Zeynep Türe, Gamze Kalin-Unuvar, Burcu Baran Ketencioğlu, Gökmen Zarasız, Tuğba Tok, Şahin Temel, Nuri Tutar, Kürşat Gündoğan, Selma Gökahmetoğlu, Bilgehan Aygen, Orhan Yıldız
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Abstract Background: We aimed to assess the risk factors for severe COVID-19 and investigate the differences between intensive care unit (ICU) and non-ICU patients. Method: The clinical, radiological, and laboratory characteristics of confirmed COVID-19 patients between March 15, 2020, and May 30, 2020, were evaluated retrospectively. Results: A total of 157 patients were included in the study. The median age of the patients was 47, and 55% were male. Seventeen of them were treated in ICU. All...
Topics: COVID 19, prognosis, risk factors, fatality, intensive care unit
A s of August 21, 2021, more than 32% of the world population has received at least one dose of the COVID-19 vaccine and almost one fourth is fully vaccinated. However, only 1.4% of the population in the developing world have received at least one dose (1). While the pandemic ravages the unvaccinated communities, a new wave of the disease is emerging in countries with high rates of full vaccination status.
Topics: COVID-19, Vaccination
Abstract Objective: Percutaneous transhepatic cholangiography (PTC) is an invasive procedure used in patients with obstructive jaundice in the progress of some malignancies, and its most common complication is infection. We aimed to evaluate the patients who underwent PTC regarding their cultures, prophylaxis, and antibiotics used for treatment. Materials and Methods: In this cross-sectional study, patients who underwent PTC and were followed up in a medical oncology outpatient clinic between...
Topics: Antibiotic prophylaxis, bacteremia, biliary tract infections, percutaneous transhepatic...
T he monkeypox (MPX) outbreak that started in the middle of May 2022 has spread to more than 30 countries, with around 8000 laboratory-confirmed cases as of July 8, 2022. It is expected to continue to spread throughout the world.
Topic: Monkeypox
The discovery of Clustered Regularly Interspaced Short Palindromic Repeat (CRISPR) and CRISPR-Associated System (Cas) have led to revolutionary advancements in almost every field of biology. The CRISPR-Cas system is part of an adaptive immune system in bacteria, and this system protects the organism from invading genetic elements of bacteriophages and plasmids. In this article, the discovery of the CRISPR-Cas system, its mechanism of action, and particularly its use in infectious diseases will...
Topics: CRISPR-Cas System, Infectious Diseases, ü
Abstract Objective: Diabetic foot infections (DFI) is one of the most important complications of diabetes mellitus. In this study, we aimed to show the causative microorganisms among patients with DFI and evaluate the long term results. Materials and Methods: We included the patients over 18 years old who were followed up with DFI, with deep tissue cultures between July 26, 2015, and November 5, 2018, in our center. Demographic data of the patients, Hba1c levels, nasal swab, tissue biopsy and...
Topics: Diabetic foot infections, tissue biopsy cultures, diabetes mellitus
Abstract Objective: We aimed to investigate the risk factors for surgical site infections (SSI) and the effectiveness of prophylactic antibiotic use. Methods: The demographic characteristics, comorbidities, and microbiological examinations of patients diagnosed with SSI who had a cholecystectomy, vaginal hysterectomy, knee prosthesis, hip prosthesis, and gastric surgery between January the 1st, 2014 and December the 31st, 2019 were retrospectively analysed. The diagnosis of...
Topics: Surgical site infection, antibiotic, resistance
The COVID-19 pandemic has been associated with a higher incidence of skin damage of the hands because of the enhanced infection prevention practices among health care workers. This article aims to share our experience and suggestions with health care workers concerning simple and effective practices to prevent and deal with the deterioration of the skin of the hands that is associated with repeated hand washing and sanitation.
Topics: COVID-19, skin damage, washing, sanitation
Abstract Background: Hydroxychloroquine (HQN) and azithromycin (AZ) were used in the treatment of coronavirus disease 2019 (Covid-19), which might lead to cardiac side effects. Aim: We aimed to describe the safety of HQN and HQN+AZ in terms of cardiac events. Materials and methods: The QTc intervals were calculated by examining the ecg records of the first day and fifth day of hospitalization the patients who received HQN with or without concominant AZ for treatment of Covid 19. ...
Topics: Qtc prolongation, COVID-19, hydroxychloroquine, azithromycin
The COVID-19 outbreak continues to spread among people around the world, despite many measures taken by governments. Wearing a single-use mask, keeping social distance and hand hygiene are the main personal protective measures and need to be applied correctly by each person in the communities. These measures are very important, especially to prevent SARS-CoV-2 virus transmission from asymptomatic persons to other people of all age.
Topics: COVID-19, face mask, social distance
Abstract A 39-year old male patient presented with severe herpes zoster ophthalmicus (HZO) on the left side of his face and developed orbital apex syndrome (OAS) despite systemic valacyclovir therapy. Persistent low vision, ptosis, limitation of extraocular muscle movements, anisocoria, epiphora, and photophobia led to suspicion of OAS. OAS was confirmed by orbital MRI. Intravenous acyclovir and systemic corticosteroids were initiated. Gradual recovery occurred over six months. The patient was...
Topics: Herpes zoster ophthalmicus, Orbital apex syndrome, Immunocompetence, Acyclovir, Optic Nerve
Abstract An illustrated case of cutaneous anthrax acquired in eastern Turkey was described in this report. A 56-year-old female patient applied to the infectious diseases outpatient clinic with a painless, dark-colored swelling over her right middle finger accompanied by edema extending to the right hand. Typical disease course of a cutaneous anthrax lesion evolved in a few days. This case report was presented in order to help clinicians to recognize the different stages of the disease in...
Topics: anthrax, cutaneous anthrax, eschar, edema
Abstract Objective: Serological tests are the most commonly used tests in the diagnosis of brucellosis; however, each serological test has some drawbacks. In this study, we aimed to determine the value of the Brucella Coombs gel test (BCGT) in the serological diagnosis of brucellosis in comparison with Standard tube agglutination (STA) and ELISA tests. Materials and Methods: The study included 42 patients who were considered to have brucellosis as a preliminary diagnosis. BCGT, Brucella-IgM/IgG...
Topics: brusellozis, coombs gel test, serological diagnosis
Over the past 38 years following the introduction of HIV infection, which affected the lives of 75 million people, many scientific advances in prevention, diagnosis, treatment and care have been recorded, and the lives of people living with HIV (PLWH) have been transformed. Currently, life expectancy for PLWH who are diagnosed early and who initiate antiretroviral treatment (ART) immediately is almost equivalent to that of HIV negative individuals.
Topic: HIV infection
Abstract Objective: Biofilm formation is one of the most important virulence factors of Candida species which leads to permanent infection foci by adhering to foreign materials and which are difficult to treat. Candida parapsilosis , which is one of the most common causes of candidemia in our country, is frequently isolated as a causative agent in catheter-related infections. The most commonly used methods for evaluating the biofilm formation of Candida species are measuring cell viability with...
Topics: C. parapsilosis, candidemia, biofilm
Abstract Fungemia due to the yeasts other than Candida is a clinically rare, but still emerging entity. The clinical terminologies of rare opportunistic yeast bloodstream infections (ROYBSIs) or micafungin breakthrough fungemia (MBF) or echinocandin non-susceptible yeast (ENSY) refer mostly to the same entity. Clinicians should be alert about the early distinction. ROYBSIs are mostly resistant to echinocandins and should be taken into consideration when yeast growth in blood culture of a...
Topics: Candidemia, Non-Candida, yeast, fungemia, echinocandin resistant, breakthrough, non-susceptible,...
T he monkeypox (MPX) outbreak that started in the middle of May 2022 has spread to more than 30 countries, with around 8000 laboratory-confirmed cases as of July 8, 2022. It is expected to continue to spread throughout the world. Human MPX is a zoonotic disease caused by the monkeypox virus (MPXV), a member of the genus Orthopoxvirus in the Poxviridae family. MPX is endemic among monkeys in Africa. Although it is not certain, rodents, especially squirrels, are suspected to be the reservoir of...
Topic: monkeypox
Infectious Diseases and Clinical Microbiology
16
16
Dec 21, 2022
12/22
by
Mehmet Gökhan Gönenli, İlker Kayı, Nilüfer Alpay-Kanıtez, Tuba Baydaş, Murat Köse, Emine Ayça Nalbantoğlu, Miraç Vural Keskinler, Timur Selçuk Akpınar, Önder Ergönül
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Abstract Objective: Throughout the pandemic, physicians working at the frontlines have embarked on various quests to protect themselves, and many physicians preferred using hydroxychloroquine (HQN) as a prophylactic agent. This study aimed to investigate the reasons leading physicians to use HQN and its effects on them. Materials and Methods: This study is cross-sectional with a target population of physicians working in pandemic hospitals in İstanbul, Turkey. We invited participants from...
Topics: COVID-19, hydroxychloroquine, prophylaxis, physicians
Abstract Herpes simplex virus is a rare cause of hepatitis in immunosuppressed and immunocompetent individuals. It can cause clinical pictures in patients ranging from an asymptomatic course to fatal acute fulminant hepatitis. Early diagnosis and treatment may be delayed if it is not suspected because of the patients’ nonspecific clinic. This study presents a case of isolated HSV-2 hepatitis in a patient with a history of cancer chemotherapy and a recent diagnosis of COVID-19 who received...
Topics: herpes simplex virus infections, herpes simplex virus-2, hepatitis, COVID-19
Infectious Diseases and Clinical Microbiology
9
9.0
Sep 26, 2022
09/22
by
Yeşim Tuyji-Tok, Ebru Yücebağ, Ayşe Betül Keleş, Ayşe Ceylan Kılınçarslan, Okan Kadir Nohut, Seda Salman-Yılmaz, Mert Ahmet Kuşkucu, Kenan Midilli
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Abstract Objective: In Turkey, the fourth wave of SARS-CoV-2 started in December 2021 and peaked in mid-January 2022. Afterward, peaks were seen in the number of COVID-19 cases because of Omicron BA.2 and BA.5 variants. Our study aimed to observe the prevalence and viral load-related transmissibility rates of the Omicron BA.2 and BA.5 variant infections in our region between January 21 and July 01, 2022, using an easy and cost-effective PCR screening method. Methods: The frequency of BA.2 and...
Topics: COVID-19, SARS-CoV-2, omicron, variant, polymerase chain reaction, next generation sequencing
Infectious Diseases and Clinical Microbiology
20
20
Dec 30, 2021
12/21
by
Oya Özlem Eren-Kutsoylu, Arzu Nazlı-Zeka, Gökçen Ömeroğlu-Şimşek, Özgür Appak, Başak Bayram, Aylin Özgen-Alpaydın, Neşe Çolak-Oray, Nur Yapar, Vildan Avkan-Oğuz
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Abstract Objective: In this study, we determined the symptoms of the COVID-19 and defined age-specific symptoms that can help diagnose the disease on hospital admission. Materials and Methods: Patients who visited a university hospital’s adult pandemia outpatient clinic with suspected COVID-19 symptoms and tested with SARS-CoV-2 polymerase chain reaction test between March 17 – May 17, 2020, were included in the study. Demographic data, symptoms on admission, prognostic laboratory tests and...
Topics: COVID-19, SARS-CoV-2, age groups, clinical features, prognosis
With this issue of the Journal , we are completing the fourth year of our publication life. As of today, we can proudly say that IDCM has greatly improved considering every aspect of a successful scientific periodical. First, in order to respond to fast increasing submission rate, we changed our publishing frequency from three times a year to quarterly. The number of original articles we published this year increased by 81% compared to 2021 (Please see the Figure 1). The rejection rate rose...
Topics: IDCM, Editorial
Abstract Objective: The frequency of Trichosporon asahii infections with high mortality rate was increased in recent years. This study aimed to genotype and to determine the antifungal susceptibility profiles of the strains isolated in our hospital. Materials and Methods: Gene sequencing analysis of 70 T. asahii strains isolated between 2006- 2016 from the clinical samples was done using IGS1 regions, and the genotypes of the strains were determined. The susceptibilities of the strains for...
Topics: genotyping, antifungal susceptibility, Trichosporon asahii Strains
Abstract We described clinical course and outcome of a patient with Listeria monocytogenes meningitis and rhombencephalitis (RE). A 65-year-old woman with past medical history of chemotherapy and radiotherapy for cervical cancer applied to emergency room with the history of fever and headache for three days. Clinical course indicating meningitis evolved to RE over time. We present this case because of the significance of early diagnosis and adequate antimicrobial therapy targeted to the...
Topics: Listeria monocytogenes, rhombencephalitis, immunocompromised host
Abstract Colistin resistance is an emerging threat. Here, we presented the development of colistin resistance in A. baumannii after colistin use on a disease course of a patient. To mimic the effects of colistin in laboratory conditions, three colistin susceptible A.baumannii isolated from the patient were exposed daily to colistin for up to 40 days. The colistin MICs and pmrABC expressions of each generation were studied. After 25 days of colistin treatment, colistin-resistant A. baumannii was...
Topics: Acinetobacter baumannii, Colistin Exposure, Laboratory Mimicking
In the treatment of COVID-19, attention is focused on expensive, high technology equipment such as sophisticated ventilators or extracorporeal membrane oxygenation (ECMO), which requires highly trained health care workers and aggressive pharmacological measures with weak evidence of efficacy. However, low-cost, primary health care has a higher life-saving potential.
Topics: COVID-19, primary health care, life-saving
Re fik Saydam (1881-1942), MD, who served as the Minister of Health for 15 years in the early period of the republic, is a well-known physician and politician who is being remembered during the current pandemic, especially in terms of fighting against epidemics and implementing preventive healthcare policies. Saydam played a significant role in the progressive steps taken by the Republic of Turkey in healthcare, implementation of healthcare policies and foundation of new institutions.
Topics: Refik Saydam, Turkey, Minister of Health, healthcare policies
A bout the last 10-year if not older, electronic learning as a training method in infectious diseases (ID) and clinical microbiology (CM) was defined as an area to be improved. In a survey published in 2017 by the European Society of Clinical Microbiology and Infectious Diseases (ESCMID), it was reported that e-learning methods were experienced by only a minority of the respondents and 43.5% of CM and 44.5% of ID trainees wanted to have more e-learning opportunities (1). Most respondents...
Topics: Virtual Learning, COVID-19, Conference, Turkish Society of Clinical Microbiology and Infectious...
Abstract Objective: We aimed to describe pathogenic contamination on healthcare workers’ cellular phones, detect factors associated with contamination, and demonstrate whether there was a link between cell phone contamination and subsequent healthcare-associated infections. Methods: The study was conducted in a 2000-bed tertiary care university hospital in Ankara. A total of 631 healthcare workers (HCWs) from several departments willing to participate were included in the study. Bacterial...
Topics: bacterial contamination, mobile phones, Healthcare Associated Infections
Abstract Bacterial meningitis is a severe infectious disease resulting in high mortality and morbidity throughout the world. The causative pathogens of bacterial meningitis depend on the patient’s age and predisposing factors. A 23-year-old pregnant woman at 36 weeks of gestation was admitted to the emergency unit with confusion and fever. She was lethargic, uncooperative, disoriented, and had been diagnosed with acute otitis media by a family physician. She had been prescribed oral...
Topics: Bacterial, meningitis, otitis media, Gram-positive, Pregnant
Dear Editor, In 2012, the American Board of Internal Medicine (ABIM) Foundation launched a health initiative campaign named Choosing Wisely to advance a national dialogue on avoiding unnecessary medical tests, treatments, and procedures. Subsequently, each specialty society developed evidence-based recommendation lists about tests and treatments that were overused and did not provide meaningful benefit for patients. Today, the Choosing Wisely campaign has partnered more than 70 societies...
Topics: choosing wisely, American Board of Internal Medicine (ABIM), urkish Society of Internal Medicine...
World Health Organization (WHO) has announced that 2021 has been designated as the International Year of Health and Care Workers (HCW) in “appreciation and gratitude for their unwavering dedication in the fight against the COVID-19 pandemic”. The theme of this one-year-long campaign is “Protect. Invest. Together.” which highlights the urgent needs such as equity and economic opportunity.
Topics: WHO, Health and Care Workers, COVID-19
Abstract Objective: Urinary tract infections are one of the most common causes of morbidity around the world. Fosfomycin is a specific broad-spectrum antibiotic used to treat these infections. However, in recent years, many studies have reported increased fosfomycin resistance in Enterobacterales isolates. Therefore, this study aimed to evaluate the distribution of pathogens isolated from urine samples and find the fosfomycin resistance rates over nine years (2012-2020). Materials and...
Topics: fosfomycin resistance, extended-spectrum beta-lactamases producing, Enterobacterales
Abstract Objective: The present study aims to define the characteristics of the necrotizing fasciitis (NF) cases followed at our hospital and to compare our results with the literature. Materials and Methods: In this study, NF cases followed and treated at our hospital from January 2005 to April 2019 were evaluated retrospectively. Results: A total of 85 cases of NF were included in the study. Of the cases, 33 (39%) were female and the median age was 59.8±13.1 years (range: 26-92 years)....
Topics: Necrotizing fasciitis, Fournier’s gangrene, necrotizing soft tissue disease
26-year-old man with acute lymphoblastic leukemia developed neutropenic fever 12 days after induction chemotherapy. The focus of infection could not be found by clinical examination, chest radiography and routine cultures and empiric antimicrobial treatment was started. As the fever persisted, computerized tomography (CT) of the thorax was performed, and a nodule with a diameter of 2 mm in the upper lobe of the right lung was detected. Absence of the lesion in the previous CT led us to think...
Topics: acute lymphoblastic leukemia, fungal infection
Coronaviruses are known to evolve slower than the other RNA viruses; however, SARS-CoV-2 underwent a major shift through D614G change in February 2020, even before the declaration of a pandemic by WHO and D614G variant became rapidly dominant throughout the world. The spike protein of this variant with D614G change have a higher affinity to human ACE-2 and gained a transmission advantage against other circulating variants. Some mutations may confer advantages for the virus, and the variants...
Topics: SARS-CoV-2, WHO, vaccines
Abstract Objective: Influenza is a systemic infectious disease. It is recommended that all pregnant women receive the influenza vaccine because the mortality of the disease is high during pregnancy. However, the rates of influenza vaccination in pregnant women are low. This study aims to estimate the rate at which Turkish gynecologists and obstetricians (GOs) recommend the influenza vaccine to their pregnant patients.. Materials and Methods: This study was designed as a cross-sectional survey....
Topics: Influenza, Influenza Vaccine, Pregnancy, Vaccination, Viral Infections
Infectious Diseases and Clinical Microbiology
6
6.0
Aug 31, 2021
08/21
by
Mehmet Yıldız, Fidan Sultanova, Hasan Selçuk Özger, Merve Büyükkörük, Kübra Erbay, Ümmügülsüm Gaygısız, Abdurrahman Tufan, Özlem Gülbahar, Fatma Zehra Özcan, Nazlı Elif Kuşcu, Deniz Gazioğlu, Beyza Çifci, Fulya Şen, Esin Şenol, Kenan Hızel, Özlem Güzel Tunçcan, Pınar Aysert Yıldız, Yeşim Yıldız, Murat Dizbay
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Abstract Background: This study aimed to evaluate the impact of tocilizumab treatment on clinical improvement in severe COVID-19 cases and the factors affecting clinical response. Methods: This single-center, retrospective, descriptive study was conducted on severe COVID-19 patients. The ordinal scale of clinical status scores on the 0th, 1st, 3rd, and 7th days of tocilizumab treatment was calculated and compared for each patient. The ordinal scale of clinical status scores calculated on...
Topics: COVID-19, tocilizumab treatment, cytokine storm
Abstract Objective: Turkey is one of the countries with the highest antibiotic consumption per capita and suffers widespread antimicrobial resistance. However, few studies are measuring the knowledge, attitude and behaviour regarding antibiotic use in Turkey. We aimed to describe the awareness, knowledge, beliefs, attitude and behaviour of the society regarding antibiotic use and antimicrobial resistance. Materials and Methods: The study was carried out at a large shopping mall with 60 000-75...
Topics: antibiotic consumption, antimicrobial resistance, awareness, knowledge, society
18-year-old male patient presented to our emergency room (ER) with complaints of swelling and temperature increase in the right wrist, pain in the right knee, and a rash without any itchiness on the palms and soles continuing for a week. He had no known systemic disease or any regular medication use. He had a history of a tick bite three months ago. The patient had neither any pet contact nor a fresh milk and cheese consumption history. Detailed anamnesis revealed that he had a sore throat a...
Topics: clinical manifestations, still’s disease
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